Patents

Edouard Alphandéry’s work carried out together with his team and collaborators recognized by:

Mark and Clerk

AlphaOnco’s patent portfolio ranked as the fourth largest in terms of number of patent submitted in Nanomedicine by Mark and Clerk.

AlphaOnco’s patent portfolio covers:

- the methods of treatment using various sources of magnetosomes excitation;
- magnetosome-based products;
- magnetosome production processes.

1st family protecting chains of magnetosomes for medical applications

Treatment of cancer or tumors induced by the release of heat generated by various chains of magnetosomes extracted from magnetotactic bacteria and submitted to an alternative magnetic field, int. publ. number: WO2011061259A1, first priority US61/262,260 filed on 18/11/2009, inventors: E. Alphandéry, S. Faure, I. Chebbi.

Magnetosomes based products, Treatment method
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Related publications

2nd family protecting the introduction of chelating agents in the medium of magnetotactic bacteria to boost bacterial growth:

Use of at least one chelating agent introduced into the culture medium of magnetotactic bacteria in order to stimulate the growth thereof, int. publ. number: WO2012/153247, first priority FR1153938 filed on 06/05/2011, inventors: E. Alphandéry, I. Chebbi.

Magnetosomes production
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Related publications

3rd family protecting non-pyrogenic magnetosomes for medical applications:

Apyrogen preparation containing nanoparticles synthesized by magnetotactic bacteria for medical or cosmetic applications, int. pub. Number WO2016203121, first priority FR1501267 filed on the 17/06/2015, inventors: E. Alphandéry, M. Durand-Dubief.

Magnetosomes based products
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Related publications

5th family protecting a method to carry out magnetic hyperthermia treatment at several frequencies of oscillations of the magnetic field:

Magnetic field oscillating at several frequencies improve efficacy and/or reduce toxicity of magnetic hyperthermia, first priority EP17290023 filed on 16/02/2017, int pub number WO2018150266, inventor: E. Alphandéry

Treatment method
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6th family protecting a method to destroy a tumor at some distance from the regions of injection of the nanoparticle and application of radiation

Magnetic nanoparticles associated to immunogenic entities for destroying pathological cells in an individual. First priority EP16290202, filed on 21/10/2016, inventor: E. Alphandéry.

Treatment method
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10th family protecting a method of treatment by cryotherapy in the presence of nanoparticles

Nanoparticle for use in a method of treating a body part of an individual by non-predominant ice-ball cryotherapy, first priorities EP20190020359, EP20190020360 submitted on 03/06/2019, inventor: E. Alphandéry

Treatment method
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11th family protecting a method to release a compound from a nanoparticle in two separate steps

Method for increasing the release of medical compounds from nanoparticles after an alteration step and physico-chemical disturbance step, int pub number WO2020217205A1, first priority FR1904404 submitted on 25/04/2019, inventor E. Alphandéry.

Treatment method
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12th family protecting a method of treatment using sequential laser application applied on magnetosomes

Magnetic nanoparticles sequentially irradiated by laser radiation for medical or biological or cosmetic applications, first priority EP20180020211 submitted on 16/05/2018, inventor: E. Alphandéry.

Treatment method
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13th family protecting a method to maintain the chain arrangement of magnetosomes after lyophilization using a magnetosome formulation containing a cryo-protectant

A method to enable nanoparticles stored with a specific type of assembly to maintain this type of assembly upon reconstitution, first priority EP20220020559 submitted on 15/11/2022, inventors:E. Alphandéry, I. Chebbi.

Magnetosomes based products
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