Scientific publications

Preclinical proof of concepts of the treatment developed by AlphaOnco have been developped pre-clinicaly and tested on different solid and organ-confined tumors.

Various thermal treatments of tumors have been developed and published by AlphaOnco.
Ultrasound has been selected for the treatment of prostate tumors.

Edouard Alphandéry’s work carried out together with his team and collaborators recognized by:

Stanford/Elsevier Top 2% Scientists List

Edouard Alphandéry ranked in the Stanford/Elsevier Top 2% Scientists List for the years 2020, 2021, 2022, 2023, 2024 and 2025.

Full Disappearance of PC3-Luc Prostate Tumors Mediated by Hyperthermia Under Low Intensity Ultrasound Application in the Presence of Magnetosomes
Pre-clinical proof of concept of AlphaOnco’s treatment on prostate tumors
Cynthia El Hedjaj, Eric Barret, Imène Chebbi, Raphaël Le Fèvre, Caroline Maake, Franco Guscetti, François Guyot, Jean-Francois Aubry, Olivier Seksek, Edouard Alphandéry. Advanced Therapeutics. Volume 8, Issue 2, February 2025.
Prostate Cancer
Biocompatibility, Magnetosomes based products, Preclinical studies, Treatment method
Publication
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Magnetic and structural properties of biogenic magnetic nanoparticles along their production process for use in magnetic hyperthermia
Magnetosome characterization at various steps of their fabrication process
C. Carvallo a, A. Fondet b, R. LeFèvre c, D. Taverna a, Y. Guyodo d, I. Chebbi c, V. Dupuis e, F. Lagroix d, M. Khelfallah a, J.-M. Guigner a, F. Guyot a, E. Alphandéry a c, A. Juhin a. Journal of Magnetism and Magnetic Materials. Volume 575, 1 June 2023, 170726.
Magnetosomes based products, R&D
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A Method for Producing Highly Pure Magnetosomes in Large Quantity for Medical Applications Using Magnetospirillum gryphiswaldense MSR-1 Magnetotactic Bacteria Amplified in Minimal Growth Media
Presentation of a method for Producing Highly Pure Magnetosomes in Large Quantity for Medical Applications
Clément Berny, Raphael Le Fèvre, François Guyot, Karine Blondeau, Christine Guizonne, Emilie Rousseau, Nicolas Bayan, Edouard Alphandéry. Front. Bioeng. Biotechnol., 18 February 2020.
Magnetosomes production, Preclinical studies
Publication
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Biodegraded magnetosomes with reduced size and heating power maintain a persistent activity against intracranial U87-Luc mouse GBM tumors
Presentation of Biodegraded magnetosomes with reduced size and heating power maintaining a persistent activity against intracranial U87-Luc mouse GBM tumors
Edouard Alphandéry, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, Florence Gazeau, François Guyot & Imène Chebbi. Journal of Nanobiotechnology volume 17, Article number: 126 (2019).
Glioblastoma
Magnetosomes based products, R&D
Publication
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Iron uptake and magnetite biomineralization in the magnetotactic bacterium Magnetospirillum magneticum strain AMB-1: An iron isotope study
Article presenting Iron uptake and magnetite biomineralization in the magnetotactic bacterium
Matthieu Amor, Vincent Busigny, Pascale Louvat, Mickaël Tharaud, Alexandre Gélabert, Pierre Cartigny, Julie Carlut, Aude Isambert, Mickaël Durand-Dubief, Georges Ona-Nguema, Edouard Alphandéry, Imène Chebbi, François Guyot. Geochimica et Cosmochimica Acta. Volume 232, 1 July 2018, Pages 225-243.
Magnetosomes based products, R&D
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