Scientific publications

Preclinical proof of concepts of the treatment developed by AlphaOnco have been developped pre-clinicaly and tested on different solid and organ-confined tumors.

Various thermal treatments of tumors have been developed and published by AlphaOnco.
Ultrasound has been selected for the treatment of prostate tumors.

Edouard Alphandéry’s work carried out together with his team and collaborators recognized by:

Stanford/Elsevier Top 2% Scientists List

Edouard Alphandéry ranked in the Stanford/Elsevier Top 2% Scientists List for the years 2020, 2021, 2022, 2023, 2024 and 2025.

Full Disappearance of PC3-Luc Prostate Tumors Mediated by Hyperthermia Under Low Intensity Ultrasound Application in the Presence of Magnetosomes
Pre-clinical proof of concept of AlphaOnco’s treatment on prostate tumors
Cynthia El Hedjaj, Eric Barret, Imène Chebbi, Raphaël Le Fèvre, Caroline Maake, Franco Guscetti, François Guyot, Jean-Francois Aubry, Olivier Seksek, Edouard Alphandéry. Advanced Therapeutics. Volume 8, Issue 2, February 2025.
Prostate Cancer
Biocompatibility, Magnetosomes based products, Preclinical studies, Treatment method
Publication
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A Method for Producing Highly Pure Magnetosomes in Large Quantity for Medical Applications Using Magnetospirillum gryphiswaldense MSR-1 Magnetotactic Bacteria Amplified in Minimal Growth Media
Presentation of a method for Producing Highly Pure Magnetosomes in Large Quantity for Medical Applications
Clément Berny, Raphael Le Fèvre, François Guyot, Karine Blondeau, Christine Guizonne, Emilie Rousseau, Nicolas Bayan, Edouard Alphandéry. Front. Bioeng. Biotechnol., 18 February 2020.
Magnetosomes production, Preclinical studies
Publication
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Biodegraded magnetosomes with reduced size and heating power maintain a persistent activity against intracranial U87-Luc mouse GBM tumors
Presentation of Biodegraded magnetosomes with reduced size and heating power maintaining a persistent activity against intracranial U87-Luc mouse GBM tumors
Edouard Alphandéry, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, Florence Gazeau, François Guyot & Imène Chebbi. Journal of Nanobiotechnology volume 17, Article number: 126 (2019).
Glioblastoma
Magnetosomes based products, R&D
Publication
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Iron uptake and magnetite biomineralization in the magnetotactic bacterium Magnetospirillum magneticum strain AMB-1: An iron isotope study
Article presenting Iron uptake and magnetite biomineralization in the magnetotactic bacterium
Matthieu Amor, Vincent Busigny, Pascale Louvat, Mickaël Tharaud, Alexandre Gélabert, Pierre Cartigny, Julie Carlut, Aude Isambert, Mickaël Durand-Dubief, Georges Ona-Nguema, Edouard Alphandéry, Imène Chebbi, François Guyot. Geochimica et Cosmochimica Acta. Volume 232, 1 July 2018, Pages 225-243.
Magnetosomes based products, R&D
Publication
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Magnetic-field induced rotation of magnetosome chains in silicified magnetotactic bacteria
Article presenting magnetic-field induced rotation of magnetosome chains in silicified magnetotactic bacteria
Marine Blondeau, Yohan Guyodo, François Guyot, Christophe Gatel, Nicolas Menguy, Imène Chebbi, Bernard Haye, Mickaël Durand-Dubief, Edouard Alphandery, Roberta Brayner & Thibaud Coradin. Scientific Reports volume 8, Article number: 7699 (2018).
Magnetosomes based products, R&D
Publication
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Biocompatible coated magnetosome minerals with various organization and cellular interaction properties induce cytotoxicity towards RG-2 and GL-261 glioma cells in the presence of an alternating magnetic field
Article presenting the preparation and characterization of magnetosomes coated with chitosan, neridronate, and PEI.
Yasmina Hamdous, Imène Chebbi, Chalani Mandawala, Raphael Le Fèvre, François Guyot, Olivier Seksek & Edouard Alphandéry. Journal of Nanobiotechnology volume 15, Article number: 74 (2017).
Glioblastoma
Magnetosomes based products, R&D
Publication
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Nanoprobe Synthesized by Magnetotactic Bacteria, Detecting Fluorescence Variations under Dissociation of Rhodamine B from Magnetosomes following Temperature, pH Changes, or the Application of Radiation
Article presenting a method to detect magnetosomes through a fluorescence de-quenching mechanism.
Edouard Alphandéry, Darine Abi Haidar, Olivier Seksek, Maxime Thoreau, Alain Trautmann, Nadege Bercovici, Florence Gazeau, François Guyot, Imène Chebbi. ACS Appl. Mater. Interfaces 2017, 9, 42, 36561–36572.
Magnetosomes based products, R&D
Publication
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Enhanced antitumor efficacy of biocompatible magnetosomes for the magnetic hyperthermia treatment of glioblastoma
Article presenting a pre-clinical proof of concept of AlphaOnco on Glioblastoma on immno-competent mice
Raphaël Le Fèvre, Mickaël Durand-Dubief, Imène Chebbi, Chalani Mandawala, France Lagroix, Jean-Pierre Valet, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, Caroline Maake, François Guyot, Edouard Alphandéry. Theranostics 2017; 7(18):4618-4631.
Glioblastoma
Magnetosomes based products, R&D
Publication
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Development of non-pyrogenic magnetosome minerals coated with poly-l-lysine leading to full disappearance of intracranial U87-Luc glioblastoma in 100% of treated mice using magnetic hyperthermia
Article presenting a pre-clinical proof of concept of AlphaOnco on intracranial Glioblastoma in the absence of endotoxins
Edouard Alphandéry a b, Ahmed Idbaih c d, Clovis Adam e, Jean-Yves Delattre c d, Charlotte Schmitt c, François Guyot a, Imène Chebbi b. Biomaterials. Volume 141, October 2017, Pages 210-222.
Glioblastoma
Magnetosomes based products, R&D
Publication
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Chains of magnetosomes with controlled endotoxin release and partial tumor occupation induce full destruction of intracranial U87-Luc glioma in mice under the application of an alternating magnetic field
Article presenting a pre-clinical proof of concept of AlphaOnco on intracranial Glioblastoma in the presence of endotoxins
Edouard Alphandéry a b, Ahmed Idbaih c d, Clovis Adam e, Jean-Yves Delattre c d, Charlotte Schmitt c d, François Guyot a, Imène Chebbi b. Journal of Controlled Release. Volume 262, 28 September 2017, Pages 259-272.
Glioblastoma
Magnetosomes based products, R&D
Publication
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