Scientific publications

Preclinical proof of concepts of the treatment developed by AlphaOnco have been developped pre-clinicaly and tested on different solid and organ-confined tumors.

Various thermal treatments of tumors have been developed and published by AlphaOnco.
Ultrasound has been selected for the treatment of prostate tumors.

Edouard Alphandéry’s work carried out together with his team and collaborators recognized by:

Stanford/Elsevier Top 2% Scientists List

Edouard Alphandéry ranked in the Stanford/Elsevier Top 2% Scientists List for the years 2020, 2021, 2022, 2023, 2024 and 2025.

Magnetic-field induced rotation of magnetosome chains in silicified magnetotactic bacteria
Article presenting magnetic-field induced rotation of magnetosome chains in silicified magnetotactic bacteria
Marine Blondeau, Yohan Guyodo, François Guyot, Christophe Gatel, Nicolas Menguy, Imène Chebbi, Bernard Haye, Mickaël Durand-Dubief, Edouard Alphandery, Roberta Brayner & Thibaud Coradin. Scientific Reports volume 8, Article number: 7699 (2018).
Magnetosomes based products, R&D
Publication
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Biocompatible coated magnetosome minerals with various organization and cellular interaction properties induce cytotoxicity towards RG-2 and GL-261 glioma cells in the presence of an alternating magnetic field
Article presenting the preparation and characterization of magnetosomes coated with chitosan, neridronate, and PEI.
Yasmina Hamdous, Imène Chebbi, Chalani Mandawala, Raphael Le Fèvre, François Guyot, Olivier Seksek & Edouard Alphandéry. Journal of Nanobiotechnology volume 15, Article number: 74 (2017).
Glioblastoma
Magnetosomes based products, R&D
Publication
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Nanoprobe Synthesized by Magnetotactic Bacteria, Detecting Fluorescence Variations under Dissociation of Rhodamine B from Magnetosomes following Temperature, pH Changes, or the Application of Radiation
Article presenting a method to detect magnetosomes through a fluorescence de-quenching mechanism.
Edouard Alphandéry, Darine Abi Haidar, Olivier Seksek, Maxime Thoreau, Alain Trautmann, Nadege Bercovici, Florence Gazeau, François Guyot, Imène Chebbi. ACS Appl. Mater. Interfaces 2017, 9, 42, 36561–36572.
Magnetosomes based products, R&D
Publication
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Enhanced antitumor efficacy of biocompatible magnetosomes for the magnetic hyperthermia treatment of glioblastoma
Article presenting a pre-clinical proof of concept of AlphaOnco on Glioblastoma on immno-competent mice
Raphaël Le Fèvre, Mickaël Durand-Dubief, Imène Chebbi, Chalani Mandawala, France Lagroix, Jean-Pierre Valet, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, Caroline Maake, François Guyot, Edouard Alphandéry. Theranostics 2017; 7(18):4618-4631.
Glioblastoma
Magnetosomes based products, R&D
Publication
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Development of non-pyrogenic magnetosome minerals coated with poly-l-lysine leading to full disappearance of intracranial U87-Luc glioblastoma in 100% of treated mice using magnetic hyperthermia
Article presenting a pre-clinical proof of concept of AlphaOnco on intracranial Glioblastoma in the absence of endotoxins
Edouard Alphandéry a b, Ahmed Idbaih c d, Clovis Adam e, Jean-Yves Delattre c d, Charlotte Schmitt c, François Guyot a, Imène Chebbi b. Biomaterials. Volume 141, October 2017, Pages 210-222.
Glioblastoma
Magnetosomes based products, R&D
Publication
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Chains of magnetosomes with controlled endotoxin release and partial tumor occupation induce full destruction of intracranial U87-Luc glioma in mice under the application of an alternating magnetic field
Article presenting a pre-clinical proof of concept of AlphaOnco on intracranial Glioblastoma in the presence of endotoxins
Edouard Alphandéry a b, Ahmed Idbaih c d, Clovis Adam e, Jean-Yves Delattre c d, Charlotte Schmitt c d, François Guyot a, Imène Chebbi b. Journal of Controlled Release. Volume 262, 28 September 2017, Pages 259-272.
Glioblastoma
Magnetosomes based products, R&D
Publication
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Biocompatible and stable magnetosome minerals coated with poly-l-lysine, citric acid, oleic acid, and carboxy-methyl-dextran for application in the magnetic hyperthermia treatment of tumors
Article presenting the preparation and characterization of magnetosomes coated with poly-l-lysine, citric acid, oleic acid, and carboxy-methyl-dextran
Chalani Mandawala, Imène Chebbi, Mickael Durand-Dubief, Raphael Le Fèvre, Yasmina Hamdous, François Guyot and Edouard Alphandéry. Journal of Materials Chemistry B. Issue 36, 2017.
Glioblastoma
Magnetosomes based products, R&D
Publication
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Chemical signature of magnetotactic bacteria
Article presenting the Chemical signature of magnetotactic bacteria
Matthieu Amor, Vincent Busigny, Mickaël Durand-Dubief, Mickaël Tharaud, Georges Ona-Nguema, Alexandre Gélabert, Edouard Alphandéry, Nicolas Menguy, Marc F. Benedetti, Imène Chebbi, and François Guyot. PNAS. January 26, 2015. 112 (6) 1699-1703.
Magnetosomes based products, R&D
Publication
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