Magnetosomes based products

Biocompatibility, Magnetosomes based products, Magnetosomes formulation, Preclinical studies

- 2025 January 19

Stable pharmaceutical composition of cryo-protected non-pyrogenic isotonic chains of magnetosomes for efficient tumor cell destruction at 45 ± 1 °C under alternating magnetic field or ultrasound application

Formulation of stable magnetosomes for injection

Tieu Ngoc Nguyen, Imène Chebbi, Raphaël Le Fèvre, François Guyot, and Edouard Alphandéry. Nanoscale, 2024,16, 18984-18997.

- 2024 May 31

Set-up of a pharmaceutical cell bank of Magnetospirillum gryphiswaldense MSR1 magnetotactic bacteria producing highly pure magnetosomes

Conditions of preparation of a pharmaceutical cell bank of magnetotactic bacteria

Théo Chades, Raphaël Le Fèvre, Imène Chebbi, Karine Blondeau, François Guyot & Edouard Alphandéry. Microbial Cell Factories volume 23, Article number: 70 (2024).

Magnetosomes based products, Magnetosomes production, Preclinical studies

- 2024 February 12

Magnetic and structural properties of biogenic magnetic nanoparticles along their production process for use in magnetic hyperthermia

Magnetosome characterization at various steps of their fabrication process

C. Carvallo a, A. Fondet b, R. LeFèvre c, D. Taverna a, Y. Guyodo d, I. Chebbi c, V. Dupuis e, F. Lagroix d, M. Khelfallah a, J.-M. Guigner a, F. Guyot a, E. Alphandéry a c, A. Juhin a. Journal of Magnetism and Magnetic Materials. Volume 575, 1 June 2023, 170726.

Biocompatibility, Magnetosomes based products, Magnetosomes formulation, Magnetosomes production, Preclinical studies, R&D, Treatment method

- 2023 June 1

Non-pyrogenic highly pure magnetosomes for efficient hyperthermia treatment of prostate cancer

Preparation of highly pure magnetosomes

Tieu Ngoc Nguyen, Imène Chebbi, Raphaël Le Fèvre, François Guyot & Edouard Alphandéry. Biotechnological Products and Process Engineering. Volume 107, pages 1159–1176, (2023).

Prostate Cancer

- 2023 January 12

Bio-synthesized iron oxide nanoparticles for cancer treatment

Review on Bio-synthesized iron oxide nanoparticles for cancer treatment

Edouard Alphandéry. International Journal of Pharmaceutics. Volume 586, 30 August 2020.

Cancer

Review

- 2020 August 30

Applications of magnetotactic bacteria and magnetosome for cancer treatment: A review emphasizing on practical and mechanistic aspects

Review on Applications of magnetotactic bacteria and magnetosome for cancer treatment

Edouard Alphandéry. Drug Discovery Today. Volume 25, Issue 8, August 2020, Pages 1444-145.

Cancer

Review

- 2020 August 12

Natural Metallic Nanoparticles for Application in Nano-Oncology

Review on Natural Metallic Nanoparticles for Application in Nano-Oncology

Edouard Alphandéry. Int. J. Mol. Sci. 2020, 21(12), 4412.

Cancer

Magnetosomes production, Preclinical studies

Review

- 2020 June 21

A Method for Producing Highly Pure Magnetosomes in Large Quantity for Medical Applications Using Magnetospirillum gryphiswaldense MSR-1 Magnetotactic Bacteria Amplified in Minimal Growth Media

Presentation of a method for Producing Highly Pure Magnetosomes in Large Quantity for Medical Applications

Clément Berny, Raphael Le Fèvre, François Guyot, Karine Blondeau, Christine Guizonne, Emilie Rousseau, Nicolas Bayan, Edouard Alphandéry. Front. Bioeng. Biotechnol., 18 February 2020.

- 2020 February 18

Biodegraded magnetosomes with reduced size and heating power maintain a persistent activity against intracranial U87-Luc mouse GBM tumors

Presentation of Biodegraded magnetosomes with reduced size and heating power maintaining a persistent activity against intracranial U87-Luc mouse GBM tumors

Edouard Alphandéry, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, Florence Gazeau, François Guyot & Imène Chebbi. Journal of Nanobiotechnology volume 17, Article number: 126 (2019).

Magnetosomes based products, Treatment method

- 2019 December 23

1st family protecting chains of magnetosomes for medical applications

Treatment of cancer or tumors induced by the release of heat generated by various chains of magnetosomes extracted from magnetotactic bacteria and submitted to an alternative magnetic field, int. publ. number: WO2011061259A1, first priority US61/262,260 filed on 18/11/2009, inventors: E. Alphandéry, S. Faure, I. Chebbi.

- 2019 November 18

Related publications

Chains of Magnetosomes Extracted from AMB-1 Magnetotactic Bacteria for Application in Alternative Magnetic Field Cancer Therapy

Iron uptake and magnetite biomineralization in the magnetotactic bacterium Magnetospirillum magneticum strain AMB-1: An iron isotope study

Article presenting Iron uptake and magnetite biomineralization in the magnetotactic bacterium

Matthieu Amor, Vincent Busigny, Pascale Louvat, Mickaël Tharaud, Alexandre Gélabert, Pierre Cartigny, Julie Carlut, Aude Isambert, Mickaël Durand-Dubief, Georges Ona-Nguema, Edouard Alphandéry, Imène Chebbi, François Guyot. Geochimica et Cosmochimica Acta. Volume 232, 1 July 2018, Pages 225-243.

- 2018 July 1

Fluorescent magnetosomes for controlled and repetitive drug release under the application of an alternating magnetic field under conditions of limited temperature increase (<2.5 °C)

Article presenting Fluorescent magnetosomes for controlled and repetitive drug release

Edouard Alphandéry, Darine Abi Haidar, Olivier Seksek, François Guyot and Imène Chebbi. Nanoscale. Issue 23, 2018.

- 2018 May 31

Magnetic-field induced rotation of magnetosome chains in silicified magnetotactic bacteria

Article presenting magnetic-field induced rotation of magnetosome chains in silicified magnetotactic bacteria

Marine Blondeau, Yohan Guyodo, François Guyot, Christophe Gatel, Nicolas Menguy, Imène Chebbi, Bernard Haye, Mickaël Durand-Dubief, Edouard Alphandery, Roberta Brayner & Thibaud Coradin. Scientific Reports volume 8, Article number: 7699 (2018).

- 2018 May 16

9th family protecting a method to purify magnetosomes through combustion

Method for removing impurities from nanoparticles, first priorities FR20180001033 and FR20180001034 submitted on 02/10/2018, inventor: E.Alphandéry.

Magnetosomes production

- 2018 February 10

8th family protecting a method to fabricate pure magnetosomes in iron by using a minimal growth medium

Cellular production of pure iron oxide nanoparticles, first priority FR1801034 submitted on 02/10/2018, inventor: E. Alphandéry.

Magnetosomes production

- 2018 February 10

13th family protecting a method to maintain the chain arrangement of magnetosomes after lyophilization using a magnetosome formulation containing a cryo-protectant

A method to enable nanoparticles stored with a specific type of assembly to maintain this type of assembly upon reconstitution, first priority EP20220020559 submitted on 15/11/2022, inventors:E. Alphandéry, I. Chebbi.

- 2017 November 15

Biocompatible coated magnetosome minerals with various organization and cellular interaction properties induce cytotoxicity towards RG-2 and GL-261 glioma cells in the presence of an alternating magnetic field

Article presenting the preparation and characterization of magnetosomes coated with chitosan, neridronate, and PEI.

Yasmina Hamdous, Imène Chebbi, Chalani Mandawala, Raphael Le Fèvre, François Guyot, Olivier Seksek & Edouard Alphandéry. Journal of Nanobiotechnology volume 15, Article number: 74 (2017).

- 2017 October 17

Nanoprobe Synthesized by Magnetotactic Bacteria, Detecting Fluorescence Variations under Dissociation of Rhodamine B from Magnetosomes following Temperature, pH Changes, or the Application of Radiation

Article presenting a method to detect magnetosomes through a fluorescence de-quenching mechanism.

Edouard Alphandéry, Darine Abi Haidar, Olivier Seksek, Maxime Thoreau, Alain Trautmann, Nadege Bercovici, Florence Gazeau, François Guyot, Imène Chebbi. ACS Appl. Mater. Interfaces 2017, 9, 42, 36561–36572.

- 2017 October 16

Enhanced antitumor efficacy of biocompatible magnetosomes for the magnetic hyperthermia treatment of glioblastoma

Article presenting a pre-clinical proof of concept of AlphaOnco on Glioblastoma on immno-competent mice

Raphaël Le Fèvre, Mickaël Durand-Dubief, Imène Chebbi, Chalani Mandawala, France Lagroix, Jean-Pierre Valet, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, Caroline Maake, François Guyot, Edouard Alphandéry. Theranostics 2017; 7(18):4618-4631.

- 2017 October 13

Development of non-pyrogenic magnetosome minerals coated with poly-l-lysine leading to full disappearance of intracranial U87-Luc glioblastoma in 100% of treated mice using magnetic hyperthermia

Article presenting a pre-clinical proof of concept of AlphaOnco on intracranial Glioblastoma in the absence of endotoxins

Edouard Alphandéry a b, Ahmed Idbaih c d, Clovis Adam e, Jean-Yves Delattre c d, Charlotte Schmitt c, François Guyot a, Imène Chebbi b. Biomaterials. Volume 141, October 2017, Pages 210-222.

- 2017 October 12

Chains of magnetosomes with controlled endotoxin release and partial tumor occupation induce full destruction of intracranial U87-Luc glioma in mice under the application of an alternating magnetic field

Article presenting a pre-clinical proof of concept of AlphaOnco on intracranial Glioblastoma in the presence of endotoxins

Edouard Alphandéry a b, Ahmed Idbaih c d, Clovis Adam e, Jean-Yves Delattre c d, Charlotte Schmitt c d, François Guyot a, Imène Chebbi b. Journal of Controlled Release. Volume 262, 28 September 2017, Pages 259-272.

- 2017 September 28

Biocompatible and stable magnetosome minerals coated with poly-l-lysine, citric acid, oleic acid, and carboxy-methyl-dextran for application in the magnetic hyperthermia treatment of tumors

Article presenting the preparation and characterization of magnetosomes coated with poly-l-lysine, citric acid, oleic acid, and carboxy-methyl-dextran

Chalani Mandawala, Imène Chebbi, Mickael Durand-Dubief, Raphael Le Fèvre, Yasmina Hamdous, François Guyot and Edouard Alphandéry. Journal of Materials Chemistry B. Issue 36, 2017.

- 2017 September 8

Mass-dependent and -independent signature of Fe isotopes in magnetotactic bacteria

Article presenting Mass-dependent and -independent signature of Fe isotopes in magnetotactic bacteria

Matthieu Amor, Vincent Busigny, Pascale Louvat, Alexandre Gélabert, Pierre Cartigny, Mickaël Durand-Dubief, Georges Ona-Nguema, Edouard Alphandéry, Imène Chebbi, and François Guyot. Science. 6 May 2016 Vol 352, Issue 6286 pp. 705-708.