Magnetosomes based products

Review

- 2015 September 24

3rd family protecting non-pyrogenic magnetosomes for medical applications:

Apyrogen preparation containing nanoparticles synthesized by magnetotactic bacteria for medical or cosmetic applications, int. pub. Number WO2016203121, first priority FR1501267 filed on the 17/06/2015, inventors: E. Alphandéry, M. Durand-Dubief.

Stable pharmaceutical composition of cryo-protected non-pyrogenic isotonic chains of magnetosomes for efficient tumor cell destruction at 45 ± 1 °C under alternating magnetic field or ultrasound application

- 2015 June 17

Related publications

Biocompatible coated magnetosome minerals with various organization and cellular interaction properties induce cytotoxicity towards RG-2 and GL-261 glioma cells in the presence of an alternating magnetic field

Chemical signature of magnetotactic bacteria

Article presenting the Chemical signature of magnetotactic bacteria

Matthieu Amor, Vincent Busigny, Mickaël Durand-Dubief, Mickaël Tharaud, Georges Ona-Nguema, Alexandre Gélabert, Edouard Alphandéry, Nicolas Menguy, Marc F. Benedetti, Imène Chebbi, and François Guyot. PNAS. January 26, 2015. 112 (6) 1699-1703.

Cancer, Other medical indications

- 2015 January 26

Applications of magnetosomes synthesized by magnetotactic bacteria in medicine

Review presenting the Applications of magnetosomes synthesized by magnetotactic bacteria in medicine

Edouard Alphandéry 1,2*. Bioeng. Biotechnol., 11 March 2014.

Review

- 2014 March 11

Use of bacterial magnetosomes in the magnetic hyperthermia treatment of tumours: A review

Review presenting the Use of bacterial magnetosomes in the magnetic hyperthermia treatment of tumours

Edouard alphandery, Imène Chebbi, François Guyot & Mickaël Durand-Dubief. International Journal of Hyperthermia. Volume 29, 2013 - Issue 8: Magnetic Nanoparticle Hyperthermia.

Cancer

Review

- 2013 September 11

Preparation of chains of magnetosomes, isolated from Magnetospirillum magneticum strain AMB-1 magnetotactic bacteria, yielding efficient treatment of tumors using magnetic hyperthermia

Article presenting magnetosome treatment of breast tumor cells.

Edouard Alphandéry a b, François Guyot a c, Imène Chebbi b. International Journal of Pharmaceutics. Volume 434, Issues 1–2, 15 September 2012, Pages 444-452.

Cancer

Magnetosomes based products, Magnetosomes production, R&D

- 2012 September 15

The effect of iron-chelating agents on Magnetospirillum magneticum strain AMB-1: stimulated growth and magnetosome production and improved magnetosome heating properties

Article presenting stimulation of the growth of magnetotactic bacteria in the presence of chelating agents.

Edouard Alphandéry, Matthieu Amor, François Guyot & Imène Chebbi. Biotechnological products and process engineering. Volume 96, pages 663–670, (2012).

- 2012 June 16

Chains of Magnetosomes Extracted from AMB-1 Magnetotactic Bacteria for Application in Alternative Magnetic Field Cancer Therapy

Article presenting the pre-clinical proof of concept of AlphaOnco’s treatment on breast tumors.

Edouard Alphandéry, Stéphanie Faure, Olivier Seksek, François Guyot, Imène Chebbi. ACS Nano. July 6, 2011.

Breast Cancer

The effect of iron-chelating agents on Magnetospirillum magneticum strain AMB-1: stimulated growth and magnetosome production and improved magnetosome heating properties

- 2011 July 6

2nd family protecting the introduction of chelating agents in the medium of magnetotactic bacteria to boost bacterial growth:

Use of at least one chelating agent introduced into the culture medium of magnetotactic bacteria in order to stimulate the growth thereof, int. publ. number: WO2012/153247, first priority FR1153938 filed on 06/05/2011, inventors: E. Alphandéry, I. Chebbi.

US9359589 |
EP12722893 |

Magnetosomes production

- 2011 May 6

Related publications

Heat Production by Bacterial Magnetosomes Exposed to an Oscillating Magnetic Field

Article presenting the mechanisms of heat production when magnetosomes are exposed to an alternating magnetic field.

E. Alphandéry*†S. Faure‡L. Raison§E. Duguet§P. A. Howse∥D. A. Bazylinski∥. J. Phys. Chem. C 2011, 115, 1, 18–22.

- 2010 December 13

Different signatures between chemically and biologically synthesized nanoparticles in a magnetic sensor: A new technology for multiparametric detection

Article presenting a method of magnetosome detection using magnetic measurements.

E. Alphandéry a, L. Lijeour b, Y. Lalatonne c d, L. Motte c. Sensors and Actuators B: Chemical Volume 147, Issue 2, 3 June 2010, Pages 786-790.

- 2010 June 3

Assemblies of Aligned Magnetotactic Bacteria and Extracted Magnetosomes: What Is the Main Factor Responsible for the Magnetic Anisotropy?

Article presenting the origin of magnetic anisotropy in aligned magnetosomes.

E. Alphandéry†Y. Ding‡A. T. Ngo†Z. L. Wang‡L. F. Wu§M. P. Pileni†*. ACS Nano 2009, 3, 6, 1539–1547.

- 2009 May 21

Difference between the Magnetic Properties of the Magnetotactic Bacteria and Those of the Extracted Magnetosomes: Influence of the Distance between the Chains of Magnetosomes

Article studying the de influence of the distance between chains of magnetosomes on their magnetic properties.

E. Alphandéry†A. T. Ngo†C. Lefèvre‡I. Lisiecki†L. F. Wu‡M. P. Pileni*†. J. Phys. Chem. C 2008, 112, 32, 12304–12309.