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Raphaël Le Fèvre, PhD

Project Manager

Raphaël Le Fevre is a former PhD CIFRE student of the company Nanobacterie and Sorbonne University. He earned his PhD in cancer biology in 2017 and subsequently joined the company as a project manager.

He specialises in bioprocess engineering, as well as in the production of magnetotactic bacteria and magnetosomes.

Related AlphaOnco publications

Magnetic and structural properties of biogenic magnetic nanoparticles along their production process for use in magnetic hyperthermia
Magnetosome characterization at various steps of their fabrication process
C. Carvallo a, A. Fondet b, R. LeFèvre c, D. Taverna a, Y. Guyodo d, I. Chebbi c, V. Dupuis e, F. Lagroix d, M. Khelfallah a, J.-M. Guigner a, F. Guyot a, E. Alphandéry a c, A. Juhin a. Journal of Magnetism and Magnetic Materials. Volume 575, 1 June 2023, 170726.
Magnetosomes based products, R&D
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Full Disappearance of PC3-Luc Prostate Tumors Mediated by Hyperthermia Under Low Intensity Ultrasound Application in the Presence of Magnetosomes
Pre-clinical proof of concept of AlphaOnco’s treatment on prostate tumors
Cynthia El Hedjaj, Eric Barret, Imène Chebbi, Raphaël Le Fèvre, Caroline Maake, Franco Guscetti, François Guyot, Jean-Francois Aubry, Olivier Seksek, Edouard Alphandéry. Advanced Therapeutics. Volume 8, Issue 2, February 2025.
Prostate Cancer
Biocompatibility, Magnetosomes based products, Preclinical studies, Treatment method
Publication
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A Method for Producing Highly Pure Magnetosomes in Large Quantity for Medical Applications Using Magnetospirillum gryphiswaldense MSR-1 Magnetotactic Bacteria Amplified in Minimal Growth Media
Presentation of a method for Producing Highly Pure Magnetosomes in Large Quantity for Medical Applications
Clément Berny, Raphael Le Fèvre, François Guyot, Karine Blondeau, Christine Guizonne, Emilie Rousseau, Nicolas Bayan, Edouard Alphandéry. Front. Bioeng. Biotechnol., 18 February 2020.
Magnetosomes production, Preclinical studies
Publication
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Biocompatible coated magnetosome minerals with various organization and cellular interaction properties induce cytotoxicity towards RG-2 and GL-261 glioma cells in the presence of an alternating magnetic field
Article presenting the preparation and characterization of magnetosomes coated with chitosan, neridronate, and PEI.
Yasmina Hamdous, Imène Chebbi, Chalani Mandawala, Raphael Le Fèvre, François Guyot, Olivier Seksek & Edouard Alphandéry. Journal of Nanobiotechnology volume 15, Article number: 74 (2017).
Glioblastoma
Magnetosomes based products, R&D
Publication
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Enhanced antitumor efficacy of biocompatible magnetosomes for the magnetic hyperthermia treatment of glioblastoma
Article presenting a pre-clinical proof of concept of AlphaOnco on Glioblastoma on immno-competent mice
Raphaël Le Fèvre, Mickaël Durand-Dubief, Imène Chebbi, Chalani Mandawala, France Lagroix, Jean-Pierre Valet, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, Caroline Maake, François Guyot, Edouard Alphandéry. Theranostics 2017; 7(18):4618-4631.
Glioblastoma
Magnetosomes based products, R&D
Publication
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Biocompatible and stable magnetosome minerals coated with poly-l-lysine, citric acid, oleic acid, and carboxy-methyl-dextran for application in the magnetic hyperthermia treatment of tumors
Article presenting the preparation and characterization of magnetosomes coated with poly-l-lysine, citric acid, oleic acid, and carboxy-methyl-dextran
Chalani Mandawala, Imène Chebbi, Mickael Durand-Dubief, Raphael Le Fèvre, Yasmina Hamdous, François Guyot and Edouard Alphandéry. Journal of Materials Chemistry B. Issue 36, 2017.
Glioblastoma
Magnetosomes based products, R&D
Publication
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