Preclinical studies

Full Disappearance of PC3-Luc Prostate Tumors Mediated by Hyperthermia Under Low Intensity Ultrasound Application in the Presence of Magnetosomes

Pre-clinical proof of concept of AlphaOnco’s treatment on prostate tumors

Cynthia El Hedjaj, Eric Barret, Imène Chebbi, Raphaël Le Fèvre, Caroline Maake, Franco Guscetti, François Guyot, Jean-Francois Aubry, Olivier Seksek, Edouard Alphandéry. Advanced Therapeutics. Volume 8, Issue 2, February 2025.

Prostate Cancer

Biocompatibility, Magnetosomes based products, Preclinical studies, Treatment method

Publication

- 2025 January 19

Stable pharmaceutical composition of cryo-protected non-pyrogenic isotonic chains of magnetosomes for efficient tumor cell destruction at 45 ± 1 °C under alternating magnetic field or ultrasound application

Formulation of stable magnetosomes for injection

Tieu Ngoc Nguyen, Imène Chebbi, Raphaël Le Fèvre, François Guyot, and Edouard Alphandéry. Nanoscale, 2024,16, 18984-18997.

Biocompatibility, Magnetosomes based products, Magnetosomes formulation, Preclinical studies

- 2024 May 31

Set-up of a pharmaceutical cell bank of Magnetospirillum gryphiswaldense MSR1 magnetotactic bacteria producing highly pure magnetosomes

Conditions of preparation of a pharmaceutical cell bank of magnetotactic bacteria

Théo Chades, Raphaël Le Fèvre, Imène Chebbi, Karine Blondeau, François Guyot & Edouard Alphandéry. Microbial Cell Factories volume 23, Article number: 70 (2024).

Magnetosomes based products, Magnetosomes production, Preclinical studies

- 2024 February 12

Non-pyrogenic highly pure magnetosomes for efficient hyperthermia treatment of prostate cancer

Preparation of highly pure magnetosomes

Tieu Ngoc Nguyen, Imène Chebbi, Raphaël Le Fèvre, François Guyot & Edouard Alphandéry. Biotechnological Products and Process Engineering. Volume 107, pages 1159–1176, (2023).

Prostate Cancer

Biocompatibility, Magnetosomes based products, Magnetosomes formulation, Magnetosomes production, Preclinical studies, R&D, Treatment method

- 2023 January 12

A Method for Producing Highly Pure Magnetosomes in Large Quantity for Medical Applications Using Magnetospirillum gryphiswaldense MSR-1 Magnetotactic Bacteria Amplified in Minimal Growth Media

Presentation of a method for Producing Highly Pure Magnetosomes in Large Quantity for Medical Applications

Clément Berny, Raphael Le Fèvre, François Guyot, Karine Blondeau, Christine Guizonne, Emilie Rousseau, Nicolas Bayan, Edouard Alphandéry. Front. Bioeng. Biotechnol., 18 February 2020.

Magnetosomes production, Preclinical studies

Publication

- 2020 February 18