Magnetic and structural properties of biogenic magnetic nanoparticles along their production process for use in magnetic hyperthermia

Magnetosome characterization at various steps of their fabrication process
C. Carvallo a, A. Fondet b, R. LeFèvre c, D. Taverna a, Y. Guyodo d, I. Chebbi c, V. Dupuis e, F. Lagroix d, M. Khelfallah a, J.-M. Guigner a, F. Guyot a, E. Alphandéry a c, A. Juhin a. Journal of Magnetism and Magnetic Materials. Volume 575, 1 June 2023, 170726.

Biodegraded magnetosomes with reduced size and heating power maintain a persistent activity against intracranial U87-Luc mouse GBM tumors

Presentation of Biodegraded magnetosomes with reduced size and heating power maintaining a persistent activity against intracranial U87-Luc mouse GBM tumors
Edouard Alphandéry, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, Florence Gazeau, François Guyot & Imène Chebbi. Journal of Nanobiotechnology volume 17, Article number: 126 (2019).

Iron uptake and magnetite biomineralization in the magnetotactic bacterium Magnetospirillum magneticum strain AMB-1: An iron isotope study

Article presenting Iron uptake and magnetite biomineralization in the magnetotactic bacterium
Matthieu Amor, Vincent Busigny, Pascale Louvat, Mickaël Tharaud, Alexandre Gélabert, Pierre Cartigny, Julie Carlut, Aude Isambert, Mickaël Durand-Dubief, Georges Ona-Nguema, Edouard Alphandéry, Imène Chebbi, François Guyot. Geochimica et Cosmochimica Acta. Volume 232, 1 July 2018, Pages 225-243.

Magnetic-field induced rotation of magnetosome chains in silicified magnetotactic bacteria

Article presenting magnetic-field induced rotation of magnetosome chains in silicified magnetotactic bacteria
Marine Blondeau, Yohan Guyodo, François Guyot, Christophe Gatel, Nicolas Menguy, Imène Chebbi, Bernard Haye, Mickaël Durand-Dubief, Edouard Alphandery, Roberta Brayner & Thibaud Coradin. Scientific Reports volume 8, Article number: 7699 (2018).

Biocompatible coated magnetosome minerals with various organization and cellular interaction properties induce cytotoxicity towards RG-2 and GL-261 glioma cells in the presence of an alternating magnetic field

Article presenting the preparation and characterization of magnetosomes coated with chitosan, neridronate, and PEI.
Yasmina Hamdous, Imène Chebbi, Chalani Mandawala, Raphael Le Fèvre, François Guyot, Olivier Seksek & Edouard Alphandéry. Journal of Nanobiotechnology volume 15, Article number: 74 (2017).

Nanoprobe Synthesized by Magnetotactic Bacteria, Detecting Fluorescence Variations under Dissociation of Rhodamine B from Magnetosomes following Temperature, pH Changes, or the Application of Radiation

Article presenting a method to detect magnetosomes through a fluorescence de-quenching mechanism.
Edouard Alphandéry, Darine Abi Haidar, Olivier Seksek, Maxime Thoreau, Alain Trautmann, Nadege Bercovici, Florence Gazeau, François Guyot, Imène Chebbi. ACS Appl. Mater. Interfaces 2017, 9, 42, 36561–36572.

Enhanced antitumor efficacy of biocompatible magnetosomes for the magnetic hyperthermia treatment of glioblastoma

Article presenting a pre-clinical proof of concept of AlphaOnco on Glioblastoma on immno-competent mice
Raphaël Le Fèvre, Mickaël Durand-Dubief, Imène Chebbi, Chalani Mandawala, France Lagroix, Jean-Pierre Valet, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, Caroline Maake, François Guyot, Edouard Alphandéry. Theranostics 2017; 7(18):4618-4631.

Development of non-pyrogenic magnetosome minerals coated with poly-l-lysine leading to full disappearance of intracranial U87-Luc glioblastoma in 100% of treated mice using magnetic hyperthermia

Article presenting a pre-clinical proof of concept of AlphaOnco on intracranial Glioblastoma in the absence of endotoxins
Edouard Alphandéry a b, Ahmed Idbaih c d, Clovis Adam e, Jean-Yves Delattre c d, Charlotte Schmitt c, François Guyot a, Imène Chebbi b. Biomaterials. Volume 141, October 2017, Pages 210-222.

Chains of magnetosomes with controlled endotoxin release and partial tumor occupation induce full destruction of intracranial U87-Luc glioma in mice under the application of an alternating magnetic field

Article presenting a pre-clinical proof of concept of AlphaOnco on intracranial Glioblastoma in the presence of endotoxins
Edouard Alphandéry a b, Ahmed Idbaih c d, Clovis Adam e, Jean-Yves Delattre c d, Charlotte Schmitt c d, François Guyot a, Imène Chebbi b. Journal of Controlled Release. Volume 262, 28 September 2017, Pages 259-272.

Biocompatible and stable magnetosome minerals coated with poly-l-lysine, citric acid, oleic acid, and carboxy-methyl-dextran for application in the magnetic hyperthermia treatment of tumors

Article presenting the preparation and characterization of magnetosomes coated with poly-l-lysine, citric acid, oleic acid, and carboxy-methyl-dextran
Chalani Mandawala, Imène Chebbi, Mickael Durand-Dubief, Raphael Le Fèvre, Yasmina Hamdous, François Guyot and Edouard Alphandéry. Journal of Materials Chemistry B. Issue 36, 2017.

Chemical signature of magnetotactic bacteria

Article presenting the Chemical signature of magnetotactic bacteria
Matthieu Amor, Vincent Busigny, Mickaël Durand-Dubief, Mickaël Tharaud, Georges Ona-Nguema, Alexandre Gélabert, Edouard Alphandéry, Nicolas Menguy, Marc F. Benedetti, Imène Chebbi, and François Guyot. PNAS. January 26, 2015. 112 (6) 1699-1703.

The effect of iron-chelating agents on Magnetospirillum magneticum strain AMB-1: stimulated growth and magnetosome production and improved magnetosome heating properties

Article presenting stimulation of the growth of magnetotactic bacteria in the presence of chelating agents.
Edouard Alphandéry, Matthieu Amor, François Guyot & Imène Chebbi. Biotechnological products and process engineering. Volume 96, pages 663–670, (2012).
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