edouard-alphandery

Edouard Alphandéry, PhD

CEO/CTO & Founder

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15+ years in oncology research

AlphaOnco (formerly Nanobacterie) is the result of over 15 years of pioneering research led by Dr. Edouard Alphandéry, an internationally recognized expert in oncological hyperthermia and the use of biological nanoparticles for cancer treatment.

His scientific journey began with a PhD in Physics from the University of Oxford, followed by postdoctoral research in biochemistry and biology at Trinity College Dublin and the University of Washington. This unique multidisciplinary background — bridging physics, chemistry, and biology — laid the foundation for his innovative work in cancer nanomedicine.

Since 2006, Dr. Edouard Alphandéry has been an Assistant Professor at Sorbonne University (formerly Paris 6). He has also served as CEO/CTO of Nanobacterie since 2008 and became a Visiting Professor at the University of Zurich in 2017, where he co-leads research on magnetosome-based cancer therapies.

Dr. Edouard Alphandéry founded AlphaOnco to translate his scientific discoveries into a novel, safe, and effective clinical solution for treating solid tumors, starting with prostate cancer.

Related AlphaOnco publications

Magnetic and structural properties of biogenic magnetic nanoparticles along their production process for use in magnetic hyperthermia
Magnetosome characterization at various steps of their fabrication process
C. Carvallo a, A. Fondet b, R. LeFèvre c, D. Taverna a, Y. Guyodo d, I. Chebbi c, V. Dupuis e, F. Lagroix d, M. Khelfallah a, J.-M. Guigner a, F. Guyot a, E. Alphandéry a c, A. Juhin a. Journal of Magnetism and Magnetic Materials. Volume 575, 1 June 2023, 170726.
Magnetosomes based products, R&D
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Full Disappearance of PC3-Luc Prostate Tumors Mediated by Hyperthermia Under Low Intensity Ultrasound Application in the Presence of Magnetosomes
Pre-clinical proof of concept of AlphaOnco’s treatment on prostate tumors
Cynthia El Hedjaj, Eric Barret, Imène Chebbi, Raphaël Le Fèvre, Caroline Maake, Franco Guscetti, François Guyot, Jean-Francois Aubry, Olivier Seksek, Edouard Alphandéry. Advanced Therapeutics. Volume 8, Issue 2, February 2025.
Prostate Cancer
Biocompatibility, Magnetosomes based products, Preclinical studies, Treatment method
Publication
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A Method for Producing Highly Pure Magnetosomes in Large Quantity for Medical Applications Using Magnetospirillum gryphiswaldense MSR-1 Magnetotactic Bacteria Amplified in Minimal Growth Media
Presentation of a method for Producing Highly Pure Magnetosomes in Large Quantity for Medical Applications
Clément Berny, Raphael Le Fèvre, François Guyot, Karine Blondeau, Christine Guizonne, Emilie Rousseau, Nicolas Bayan, Edouard Alphandéry. Front. Bioeng. Biotechnol., 18 February 2020.
Magnetosomes production, Preclinical studies
Publication
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Biodegraded magnetosomes with reduced size and heating power maintain a persistent activity against intracranial U87-Luc mouse GBM tumors
Presentation of Biodegraded magnetosomes with reduced size and heating power maintaining a persistent activity against intracranial U87-Luc mouse GBM tumors
Edouard Alphandéry, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, Florence Gazeau, François Guyot & Imène Chebbi. Journal of Nanobiotechnology volume 17, Article number: 126 (2019).
Glioblastoma
Magnetosomes based products, R&D
Publication
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Magnetic-field induced rotation of magnetosome chains in silicified magnetotactic bacteria
Article presenting magnetic-field induced rotation of magnetosome chains in silicified magnetotactic bacteria
Marine Blondeau, Yohan Guyodo, François Guyot, Christophe Gatel, Nicolas Menguy, Imène Chebbi, Bernard Haye, Mickaël Durand-Dubief, Edouard Alphandery, Roberta Brayner & Thibaud Coradin. Scientific Reports volume 8, Article number: 7699 (2018).
Magnetosomes based products, R&D
Publication
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Biocompatible coated magnetosome minerals with various organization and cellular interaction properties induce cytotoxicity towards RG-2 and GL-261 glioma cells in the presence of an alternating magnetic field
Article presenting the preparation and characterization of magnetosomes coated with chitosan, neridronate, and PEI.
Yasmina Hamdous, Imène Chebbi, Chalani Mandawala, Raphael Le Fèvre, François Guyot, Olivier Seksek & Edouard Alphandéry. Journal of Nanobiotechnology volume 15, Article number: 74 (2017).
Glioblastoma
Magnetosomes based products, R&D
Publication
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Enhanced antitumor efficacy of biocompatible magnetosomes for the magnetic hyperthermia treatment of glioblastoma
Article presenting a pre-clinical proof of concept of AlphaOnco on Glioblastoma on immno-competent mice
Raphaël Le Fèvre, Mickaël Durand-Dubief, Imène Chebbi, Chalani Mandawala, France Lagroix, Jean-Pierre Valet, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, Caroline Maake, François Guyot, Edouard Alphandéry. Theranostics 2017; 7(18):4618-4631.
Glioblastoma
Magnetosomes based products, R&D
Publication
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Chains of magnetosomes with controlled endotoxin release and partial tumor occupation induce full destruction of intracranial U87-Luc glioma in mice under the application of an alternating magnetic field
Article presenting a pre-clinical proof of concept of AlphaOnco on intracranial Glioblastoma in the presence of endotoxins
Edouard Alphandéry a b, Ahmed Idbaih c d, Clovis Adam e, Jean-Yves Delattre c d, Charlotte Schmitt c d, François Guyot a, Imène Chebbi b. Journal of Controlled Release. Volume 262, 28 September 2017, Pages 259-272.
Glioblastoma
Magnetosomes based products, R&D
Publication
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Development of non-pyrogenic magnetosome minerals coated with poly-l-lysine leading to full disappearance of intracranial U87-Luc glioblastoma in 100% of treated mice using magnetic hyperthermia
Article presenting a pre-clinical proof of concept of AlphaOnco on intracranial Glioblastoma in the absence of endotoxins
Edouard Alphandéry a b, Ahmed Idbaih c d, Clovis Adam e, Jean-Yves Delattre c d, Charlotte Schmitt c, François Guyot a, Imène Chebbi b. Biomaterials. Volume 141, October 2017, Pages 210-222.
Glioblastoma
Magnetosomes based products, R&D
Publication
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Chemical signature of magnetotactic bacteria
Article presenting the Chemical signature of magnetotactic bacteria
Matthieu Amor, Vincent Busigny, Mickaël Durand-Dubief, Mickaël Tharaud, Georges Ona-Nguema, Alexandre Gélabert, Edouard Alphandéry, Nicolas Menguy, Marc F. Benedetti, Imène Chebbi, and François Guyot. PNAS. January 26, 2015. 112 (6) 1699-1703.
Magnetosomes based products, R&D
Publication
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Iron uptake and magnetite biomineralization in the magnetotactic bacterium Magnetospirillum magneticum strain AMB-1: An iron isotope study
Article presenting Iron uptake and magnetite biomineralization in the magnetotactic bacterium
Matthieu Amor, Vincent Busigny, Pascale Louvat, Mickaël Tharaud, Alexandre Gélabert, Pierre Cartigny, Julie Carlut, Aude Isambert, Mickaël Durand-Dubief, Georges Ona-Nguema, Edouard Alphandéry, Imène Chebbi, François Guyot. Geochimica et Cosmochimica Acta. Volume 232, 1 July 2018, Pages 225-243.
Magnetosomes based products, R&D
Publication
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Nanoprobe Synthesized by Magnetotactic Bacteria, Detecting Fluorescence Variations under Dissociation of Rhodamine B from Magnetosomes following Temperature, pH Changes, or the Application of Radiation
Article presenting a method to detect magnetosomes through a fluorescence de-quenching mechanism.
Edouard Alphandéry, Darine Abi Haidar, Olivier Seksek, Maxime Thoreau, Alain Trautmann, Nadege Bercovici, Florence Gazeau, François Guyot, Imène Chebbi. ACS Appl. Mater. Interfaces 2017, 9, 42, 36561–36572.
Magnetosomes based products, R&D
Publication
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Biocompatible and stable magnetosome minerals coated with poly-l-lysine, citric acid, oleic acid, and carboxy-methyl-dextran for application in the magnetic hyperthermia treatment of tumors
Article presenting the preparation and characterization of magnetosomes coated with poly-l-lysine, citric acid, oleic acid, and carboxy-methyl-dextran
Chalani Mandawala, Imène Chebbi, Mickael Durand-Dubief, Raphael Le Fèvre, Yasmina Hamdous, François Guyot and Edouard Alphandéry. Journal of Materials Chemistry B. Issue 36, 2017.
Glioblastoma
Magnetosomes based products, R&D
Publication
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The effect of iron-chelating agents on Magnetospirillum magneticum strain AMB-1: stimulated growth and magnetosome production and improved magnetosome heating properties
Article presenting stimulation of the growth of magnetotactic bacteria in the presence of chelating agents.
Edouard Alphandéry, Matthieu Amor, François Guyot & Imène Chebbi. Biotechnological products and process engineering. Volume 96, pages 663–670, (2012).
Magnetosomes based products, Magnetosomes production, R&D
Publication
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